An Observational Cohort Study of Targeted Antibiotic Treatments of Cystic Fibrosis Exacerbations.

ABSTRACT:

Background

Cystic fibrosis (CF) pulmonary exacerbations shorten survival. Treatment guidelines omit minimal inhibitory concentration (MIC)-based antibiotic dose selection. We tested whether MIC-guided intravenous antibiotic strategies prolong time between exacerbations.

Methods

We retrospectively studied randomly chosen intravenous antibiotic-treated pulmonary exacerbations from 2015 to 2018, followed through 2021. Using pre-admission sputum culture-derived MICs to select dosing targets, we estimated measured:target ratios for β-lactam steady-state and aminoglycoside area under the curve pharmacokinetics. We used Kaplan-Meier and Cox proportional hazards methods to test whether measured:target ratios were associated with time to next exacerbation. We evaluated serial laborat

SUBMITTER: Jacobs HR 

PROVIDER: S-EPMC12809580 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature