Rapid and Sensitive Quantification of Nano- and Microplastics in Water, Sediment, and Biological Tissue by Pyrolysis-Gas Chromatography Tandem Mass Spectrometry with Dynamic Reaction Monitoring.

ABSTRACT: A highly sensitive and selective method was developed for the quantification of nano- and microplastics (NMPs) in water, sediments, and biological tissues using pyrolysis gas chromatography coupled with triple quadrupole mass spectrometry (Py-GC-qQq-MS). Dynamic multiple reaction monitoring (DMRM) and internal standard calibration enabled quantification of 12 common polymers at nanogram levels (1-126 ng). Sample preparation and cleanup was matrix-specific, employing filtration, enzymatic digestion, or pressurized liquid extraction. The addition of calcium carbonate (CaCO₃) enhanced signal intensity for several polymers, while tandem mass spectrometry ensured high specificity and sensitivity. Lipid interference for the major plastics polyethylene, polypropylene and nylon-66 was a

SUBMITTER: Gahn MB 

PROVIDER: S-EPMC12809636 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature