Impact of autologous blood transfusions on surface marker and microRNA profiles of urinary extracellular vesicles.

ABSTRACT: Aim: Autologous blood transfusions (ABT), especially those involving stored erythrocyte concentrates (ECs), are known to be misused as performance enhancers in recreational and competitive athletes. EC storage not only increases the release of extracellular vesicles (EVs), but also significantly alters the microRNA profiles. Since re-transfused EVs also appear in urine, this study was designed to evaluate whether the urinary EV-associated microRNA load could serve as a valuable indicator in the challenging detection of ABT. Methods: Thirty healthy, recreationally active males were included and equally divided into three groups. The control group did not donate or receive any blood components. Group 1 donated about 500 mL of whole blood once, which was subsequently processed i

SUBMITTER: Mussack V 

PROVIDER: S-EPMC12809685 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature