Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

ABSTRACT:

Background

Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation involves the interplay between lipid metabolism and skeletal muscle health. Using data from the Studies Investigating Comorbidities Aggravating Heart Failure, we investigated whether an association exists between low-density lipoprotein cholesterol (LDL-C) levels and all-cause mortality in patients with chronic HF in the context of skeletal muscle mass.

Methods

A total of 241 patients with chronic HF (68 ± 11 years, 80% male, left ventricular ejection fraction 39

SUBMITTER: Sato R 

PROVIDER: S-EPMC12809719 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature