Esophagus extracellular matrix with microenvironmental complexity for esophageal organoids.

ABSTRACT: Esophageal organoids have the potential to serve as promising therapeutics for esophageal mucosal damage, but their application remains largely unexplored. A critical initial step in this application involves addressing the challenges posed by Matrigel (MAT)-based conventional organoid culture, as its tumor-derived origin hinders clinical applications. In this study, we demonstrate the application of decellularized esophagus-derived extracellular matrix (EEM) to the culture and transplantation of esophageal organoids, inspired by excellent biocompatibility and esophageal mimicry of EEM. Our comprehensive proteomic analysis reveals that EEM recapitulates microenvironmental complexity suitable for esophageal organoids by providing diverse esophagus-specific proteins absent in MAT. Esophageal

SUBMITTER: Park S 

PROVIDER: S-EPMC12809746 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature