Novel Synergistic Strategy for Enhanced Performance in NIR-II FI-PAI-MRI Trimodal Imaging.

ABSTRACT: The integration of emerging imaging modalities, such as fluorescence imaging (FI) and photoacoustic imaging (PAI), with conventional techniques like magnetic resonance imaging (MRI), not only mitigates the former's limitations in tissue penetration depth but also compensates for the latter's shortcomings in temporal resolution and molecular sensitivity. This study proposed an emerging strategy for multifunctional synergistic enhancement of imaging performance. Specifically, a triple-modality imaging probe capable of near-infrared-II (NIR-II) FI-PAI-MRI has been constructed, which coencapsulated the NIR-I fluorophore ICG, NIR-II fluorophore IR-1061, and ultrasmall copper sulfide quantum dots (u-Cu_2-x S QDs). The results demonstrated that co-loading ICG and IR-1061 enables

SUBMITTER: Yu H 

PROVIDER: S-EPMC12809760 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature