Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences.

ABSTRACT:

Background and hypothesis

Persistent distressing psychotic-like experiences (PLE) are associated with impaired functioning and future psychopathology. Prior research suggests that physical activities may be protective against psychopathology. However, it is unclear whether physical activities may interact with genetics in the development of psychosis.

Study design

This study included 4679 participants of European ancestry from the Adolescent Brain Cognitive Development Study. Persistent distressing PLE was derived from the Prodromal-Questionnaire-Brief Child Version using four years of data. Generalized linear mixed models tested the association between polygenic risk score for schizophrenia (PRS-SCZ), physical activities, and PLE. The models adjusted for age, sex, parental

SUBMITTER: Ku BS 

PROVIDER: S-EPMC12809793 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature