Rheological Properties of Hemoglobin-Based Physical and Chemical Gels, and Their Hybrid.

ABSTRACT: Gel viscoelasticity governs the mechanical identity of functional biomaterials. This paper presents the design and rheological characterization of hemoglobin (Hb)-based hydrogels, in which the network is maintained either by native Hb or by intramolecularly ββ-cross-linked Hb (XLHb). Native Hb has a α₂β₂ structure constructed via reversible, noncovalent interactions between αβ subunits, whereas in XLHb the tetrameric α₂β₂ structure is stabilized covalently. Conjugation of the β subunits of native Hb with four-armed 10 kDa polyethylene glycol (PEG) produces a physically cross-linked supramolecular gel exhibiting liquid-like viscoelasticity and self-healing behavior. By contrast, XLHb yields a chemically cross-linked gel exhibiting solid-like mecha

SUBMITTER: Matsuhira T 

PROVIDER: S-EPMC12809794 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature