PI3K/AKT/eNOS Modulation and Angiotensin II Suppression by <i>Dryopteris crassirhizoma</i> Rhizome Extract: Computational and Experimental Evidence.

ABSTRACT: The rhizome of Dryopteris crassirhizoma (DC) Nakai has long been prescribed in Chinese and Korean medicine to treat parasitic infestations, colds, and hemorrhages. DC is rich in antioxidant phytochemicals that may enhance endothelial nitric oxide bioavailability, thereby promoting vasorelaxation; however, this potential has not been thoroughly investigated. Absorption, distribution, metabolism, excretion, and toxicity-screened DC constituents were retrieved from Traditional Chinese Medicine Systems Pharmacology and incorporated into herb-compound-target-disease and protein-protein interaction networks. Network pharmacology analysis, combined with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment, identified the phosphoinositide 3-kinase/Akt/endothelial nitric oxid

SUBMITTER: Kim J 

PROVIDER: S-EPMC12809805 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature