Relationship Between Clozapine-Induced Inflammation and Eosinophilia: A Retrospective Cohort Study.

ABSTRACT:

Background and hypothesis

Eosinophilia has not been highlighted in clozapine-induced adverse inflammatory events, as it is often asymptomatic and self-limiting, while drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome occurs rarely. This study aimed to reveal the temporal relationships between eosinophilia and other inflammatory events during clozapine initiation.

Study design

The temporal relationships between eosinophilia and other inflammatory events were evaluated among 241 patients with schizophrenia treated with clozapine for the first time at 7 hospitals. Risk factors for eosinophilia were investigated among preceding inflammatory events and other clinical characteristics. Furthermore, patients with eosinophilia were stratified by the severity of a

SUBMITTER: Kikuchi Y 

PROVIDER: S-EPMC12809819 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature