Design, Synthesis, and Antibacterial Evaluation of Pyrido[2,3‑<i>d</i>]Pyrimidine and Pyrido[3,2‑<i>e</i>]Pyrimido[1,2‑<i>c</i>]Pyrimidine Derivatives.

ABSTRACT: A new series of N-substituted pyrido2,3-dpyrimidines and pyrido-[3,2-e]-pyrimido-[1,2-c]-pyrimidine derivatives were synthesized. The synthesis was initiated from pyridopyrimidin-4-(3H)-one derivatives which were prepared via a tandem Pinner/Dimroth rearrangement in the presence of phosphoryl chloride. Its N-substituted derivatives were prepared after treatment of chloro-derivative with a series of amines, and then some of these derivatives underwent cyclization to give the tricyclic derivatives. The fused pyridopyrimidopyrimidines were obtained via the reaction of amino compound with malonates derivatives. Most of these compounds were evaluated for their antibacterial activity. The structures of the synthesized compounds were confirmed by elemental analysis and spectr

SUBMITTER: El-Essawy FA 

PROVIDER: S-EPMC12809839 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature