Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia.

ABSTRACT:

Background and hypothesis

Disorganized thinking is a prominent feature of schizophrenia that becomes persistent in the presence of treatment resistance. Disruption of the default mode network (DMN), which regulates self-referential thinking, is now a well-established feature of schizophrenia. However, we do not know if DMN disruption affects disorganization and contributes to treatment-resistant schizophrenia (TRS).

Study design

This study investigated the DMN in 48 TRS, 76 non-TRS, and 64 healthy controls (HC) using a spatiotemporal approach with resting-state functional magnetic resonance imaging. We recovered DMN as an integrated network using multivariate group independent component analysis and estimated its loading coefficient (reflecting spatial prominence) and Shanno

SUBMITTER: Huang H 

PROVIDER: S-EPMC12809848 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature