Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.

ABSTRACT:

Background

Psychiatric research is increasingly embracing a paradigm shift from categorical diagnoses to neurobiologically meaningful dimensions that cross current diagnostic boundaries. This transposition calls for redefining endophenotypes to accommodate transdiagnostic vulnerabilities. We sought to identify shared and disorder-specific neurocognitive endophenotypes for schizophrenia, bipolar I disorder (BD-I) and a broad psychosis/BD-I phenotype in a mega-analysis of twin/sibling data.

Study design

We performed genetic model fitting to intelligence (IQ) and computerised neurocognitive data derived from 1050 twins/siblings from three research centres in the UK, Denmark and the Netherlands, affected (n = 257) or unaffected (n = 793) by schizophrenia, other primary psychoses

SUBMITTER: Kravariti E 

PROVIDER: S-EPMC12809861 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature