Bioactive Glass-Inspired Coating for Implants via Plasma Electrolytic Oxidation: A Preclinical Approach to Enhance Bone Repair in Healing-Impaired Conditions Associated with Diabetes.

ABSTRACT: Diabetes mellitus is a globally prevalent metabolic disorder that impairs wound healing and bone regeneration, compromising outcomes in implant therapies that rely on osseointegration. Advances in precision medicine and bioengineering have driven the development of functionalized implant surfaces to overcome these limitations. Among them, bioactive glass (BG) coatings have emerged as promising candidates to enhance biological responses. Building upon this rationale, we unveiled the osteoinductive potential of a BG-based coating synthesized via plasma electrolytic oxidation (PEO) and its effects on peri-implant bone regeneration in a diabetic rat model. Titanium implants were treated with PEO using a formulation mimicking BG composition (∼45.0 Si, 24.5 Ca, 24.5 Na, 6.0 P; m/v %), and the re

SUBMITTER: Barbosa Alves da Cruz S 

PROVIDER: S-EPMC12809862 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature