Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.

ABSTRACT: The development and regeneration of multicellular organisms require dynamic coordination between cellular behaviors and mechanochemical signals to achieve precise and stable tissue shapes. Plastic organisms, such as planarians, can regenerate, grow, and degrow as adults while maintaining precise whole-body and organ tissue shapes. However, the mechanisms underlying the pathways that coordinate and integrate these signals into the correct balance between cellular growth, mitosis, and apoptosis to form emergent target tissue shapes remain poorly understood. Here, we present a systematic theoretical study of the biological drivers controlling the feedback mechanisms between tissue growth and morphogen signaling. The approach is based on lattice-free, center-based simulations of cell size dyna

SUBMITTER: Kaity B 

PROVIDER: S-EPMC12809879 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature