A selective fluorescent probe for an organophosphorous nerve agent mimic <i>via</i> an oxime-to-isoxazole cascade reaction.

ABSTRACT: A class of chemical warfare agents and their facile use in terrorist attacks underscores the need to develop accurate system to detect these chemicals. For this paper, we synthesized and developed a new highly selective and sensitive fluorescence probe based on fluoresceinyloxime for the detection of a nerve agent mimic. The synthesized probe underwent an abnormal cascade reaction from oxime to isoxazole in DMF/HEPES buffer (1/1, v/v, pH 7.0). The probe responded by quenching the fluorescence intensity in very short time (within seconds) and gave a naked eye detection by changing the colour of the solution from dark orange to very light green with a detection limit of 0.18 µM. The probe not only shows sensitivity and selectivity in the liquid phase, but can also be applied for the detectio

SUBMITTER: Khan MSJ 

PROVIDER: S-EPMC12809880 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature