Combined resistance training and amino acid-based supplementation for sarcopenia in older adults: a systematic review and meta-analysis.

ABSTRACT:

Background and objective

Resistance training is the cornerstone of sarcopenia management. However, whether combining it with amino acid-based supplementation, including essential amino acids, branched-chain amino acids, leucine, and derivatives such as HMB, provides additional benefits remains unclear.

Methods

We systematically searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials until February 2025. Meta- and subgroup analyses were performed using a random-effects model. The Cochrane ROB2 tool and GRADE framework were used to assess the risk of bias and evidence certainty.

Results

We included nine randomized controlled trials involving 496 participants with sarcopenia. Evidence rated as low to very low certainty indicated th

SUBMITTER: Xie C 

PROVIDER: S-EPMC12809905 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature