Fibulin-5 promotes fibroblast activation through LTBP-4 to improve the pathogenesis of hemorrhoids.

ABSTRACT:

Background

Hemorrhoid disease is a widespread gastrointestinal ailment caused by the degeneration of supporting tissues within the anal cushions. Despite its high incidence, the pathogenic processes involved remain poorly elucidated.

Objective

This study sought to clarify the functions of Fibulin-5 (FBLN5) and latent transforming growth factor beta binding protein 4 (LTBP-4) in activating fibroblasts and their combined impact on hemorrhoid pathogenesis, while exploring their potential as therapeutic targets.

Methods

A rat model of hemorrhoid was created by injecting glacial acetic acid into the region surrounding the anus. Fibroblast migration was assessed using a scratch test, while cell viability was assessed with CCK-8. Protein and gene expression levels of FBLN5,

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12809937 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature