Remarkable heterogeneity revealed in the genetic architecture of resistance to a key bacterial pathogen in two commercial rainbow trout populations.

ABSTRACT:

Background

Bacterial cold-water disease (BCWD), caused by Flavobacterium psychrophilum, remains a major challenge for rainbow trout (Oncorhynchus mykiss) aquaculture, due to the absence of effective vaccines and increasing concerns over antibiotic use. Genetic selection for disease resistance offers a sustainable alternative. In this study, we investigated the genetic architecture of BCWD resistance in two French commercial rainbow trout populations using a standardized waterborne infection model and high-density SNP genotyping.

Results

Survival following experimental infection varied significantly between populations, with population B showing higher resistance (71.3% vs. 50.7% of survival at 29 days post-infection). Genome-wide association studies (GWAS) were performed usi

SUBMITTER: Pouil S 

PROVIDER: S-EPMC12809949 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature