HMGB1 and metabolic pathways in Acinetobacter baumannii pneumonia: an associative study.

ABSTRACT:

Background

Acinetobacter baumannii (AB) pneumonia often leads to lung injury and multisystem dysfunction. High Mobility Group Box 1 (HMGB1) is known to play a crucial role in the progression of AB. In this study, we aimed to investigate the association between HMGB1 levels and the severity of AB pneumonia.

Methods

We conducted a study with a total of 91 participants, divided into three groups: patients with AB infection (n = 44), patients with AB complicated multiple organ disfunctions (MODs) (n = 19), and healthy controls (n = 28). Clinical parameters were assessed, HMGB1 levels were measured, and metabolomic analysis was performed. Validation experiments were conducted using SD rats.

Results

Patients with AB exhibited significantly elevated levels of HMGB1. In the m

SUBMITTER: Xue M 

PROVIDER: S-EPMC12809963 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature