Investigation of Transdermal Drug Delivery and In Vivo Pharmacokinetics of Choline Ketoprofen Ionic Liquid.

ABSTRACT: To solve the bioavailability of nonsteroidal anti-inflammatory drugs and reduce their clinical risks, this study combined density functional theory (DFT) calculations with experiments and investigated the mechanism of in vitro transdermal absorption of choline ketoprofen gel and the pharmacokinetics of choline ketoprofen in rats. High-performance liquid chromatography (HPLC) was used to analyze the in vitro transdermal effect of ketoprofen in rats and the concentration of ketoprofen in the plasma of rats, which were administered choline ketoprofen by gavage. After the transdermal treatment, the rat skin was subjected to Hematoxylin and Eosin (H&E) staining and observe changes in skin structure. The results indicate that choline ketoprofen gel is superior to ketoprofen gel in terms of trans

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12810038 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature