Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.

ABSTRACT: The human cortical inhibitory system is known to play a vital role for normal brain development, function, and plasticity. GABA is the most prominent inhibitory neurotransmitter in the CNS and is a key regulator not only for motor control and motor learning, but also for cognitive processes. With ageing and many neurodegenerative pathologies, a decline in GABAergic function in several cortical regions together with a reduced ability to task-specifically modulate and increase inhibition in the primary motor cortex has been observed. This decline in intracortical inhibition is associated with impaired motor control but also with diminished motor-cognitive (i.e. dual-tasking) and cognitive performance (e.g. executive functions). Furthermore, more general well-being such as sleep quality, stre

SUBMITTER: Taube W 

PROVIDER: S-EPMC12810228 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature