Identification of Neuroactive Chemicals in Crude Oil-Derived Water-Accommodated Fractions.

ABSTRACT: Crude oil-derived water-accommodated fractions (WAFs) are complex mixtures containing bioavailable constituents. We applied an automated zebrafish behavior-based assay to assess potential neuroactivity following exposure to WAF and chemical fractions including polycyclic aromatic hydrocarbons (PAHs), resin, naphthalene (NAP), monoaromatic hydrocarbon (MAH), and saturate fractions. Zebrafish larvae were exposed to WAF concentrations (9.8-100%, 1 g/L loading) and assessed using the 26-end point visual and acoustic motor response assay at 5 day postfertilization. WAF exposure elicited concentration-dependent behavioral effects, including reduced dark-period activity, impaired acoustic startle responses, and inappropriate activity during light and typically quiescent interstimulus periods. All

SUBMITTER: Herold NK 

PROVIDER: S-EPMC12810237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature