The relationship between testosterone replacement therapy and incidence of proximal humerus fractures in men: a matched retrospective analysis.

ABSTRACT:

Background

Anabolic androgenic steroid supraphysiologic dose use is linked to an increased risk of tendon rupture. Testosterone replacement therapy (TRT) is used to treat hypogonadism and is associated with increased bone mineral density. However, its relationship with fracture risk, particularly proximal humerus fractures (PHF), remains uncertain. This study evaluates the association between TRT and the incidence of PHFs using a large national database. We hypothesized that TRT use would be associated with a difference in the incidence of PHFs compared to a control group due to testosterone's role in maintaining bone mineral density.

Methods

This retrospective study with one-to-one matching queried the PearlDiver Mariner165 dataset to obtain a random sample of 500,000 patie

SUBMITTER: Arcand PH 

PROVIDER: S-EPMC12810334 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature