Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

ABSTRACT:

Objective

Pregnancy induces profound immunological adaptations that usually promote tolerance and reduce autoimmune activity. However, women with systemic lupus erythematosus (SLE) remain at increased risk of disease flares and pregnancy complications, whereas rheumatoid arthritis (RA) often improves during gestation. To better understand this divergence, we longitudinally characterized transcriptomic and microRNA (miRNA) changes in circulating monocytes from healthy, RA, and SLE pregnancies.

Methods

Pregnant women with SLE (n = 5), RA (n = 4), and healthy controls (n = 5) were followed from preconception to three months postpartum. CD14⁺ monocytes were isolated at each visit and profiled using RNA sequencing and miRNA sequencing. Differential expression analyses

SUBMITTER: Scherlinger M 

PROVIDER: S-EPMC12810336 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature