Amygdala-insula response to neutral stimuli and the prospective prediction of anxiety sensitivity.

ABSTRACT:

Background

Anxiety sensitivity (AS) - the tendency to perceive benign physiological stimuli as harmful - is a risk factor for anxiety disorders. Cross-sectionally, AS has been linked to increased negative > neutral neural activity in key nodes implicated in threat detection and interoceptive - i.e., the amygdala (AMYG) and insula (INS). Examining the unique contributions of AMYG-INS blood‑oxygen-level-dependent (BOLD) response to neutral and negative stimuli to the prospective prediction of AS could increase understanding of the factors predisposing individuals to worsening AS over time.

Methods

Forty-six participants, including 33 patients with mixed internalizing disorders, underwent fMRI scans to assess insula and amygdala activation in response to neutral and negative pi

SUBMITTER: MacDonald SE 

PROVIDER: S-EPMC12810358 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature