Psychosocial stressors as modifiers of the associations between well-studied and understudied chemicals and birth outcomes in the ECHO Cohort.

ABSTRACT: Psychosocial stressors may exacerbate observed associations between environmental toxicants and adverse birth outcomes. However, studies have primarily focused on well-known compounds rather than a broader range of chemicals of concern. Pregnant women in this analysis had a prenatal urine sample analyzed for 113 well-studied and understudied chemical analytes, and at least one measure of psychosocial stress (N = 1566). We measured analytes from 10 chemical classes, including fungicides/herbicides, insecticides, halogenated phenols, organophosphorus flame retardants, benzophenones, bisphenols, parabens, antimicrobials, phthalates/alternative plasticizers, and polycyclic aromatic hydrocarbons. Principal component analysis was used to identify clusters of exposure patterns. Generalized Estima

SUBMITTER: Eick SM 

PROVIDER: S-EPMC12810359 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature