Both Oocyte Hyperresponse and Oocyte Vitrification Are Safe Procedures Regarding Embryo Euploidy: A Real-World Study Involving Almost 200 000 Oocytes.

ABSTRACT:

Purpose

To ascertain whether ovarian hyperresponse and oocyte vitrification (OV) are associated with an increase in embryo aneuploidy.

Methods

Retrospective study involving 197 629 retrieved oocytes. We studied the euploidy rate (ER), the ER according to the number of retrieved oocytes (ERaRO) and according to the number of metaphase II oocytes (MIIO) (ERaMII), and the quotient "MIIO/retrieved oocytes" or mature oocyte rate (MOR).

Results

The maximal ERaRO corresponded when only one oocyte was recovered (27% ± 44%), and was somewhat lower when two oocytes were retrieved (14% ± 31%). From the 3rd oocyte until the 36th oocyte, the ERaRO remained constant at around 10%. Regarding MIIO, a similar pattern was observed. For a given number of oocytes, usually the ER was high

SUBMITTER: Matorras R 

PROVIDER: S-EPMC12810404 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature