Bimodal Mechanical Response of Membrane Necks: Implications for the Nuclear Envelope.

ABSTRACT: Among the fascinating shapes that biomembranes exhibit are stomatocytes with multiple membrane necks, found for example in nuclear membranes and open autophagosomes. These morphologies, characterized by a high topological genus, can be visualized as spherical double membranes connected by neck-like structures. The necks are often occupied by specific biomolecular complexes, such as the nuclear pore complex, which divide the space into three distinct compartments. Understanding how the size of these necks responds to pressure gradients is fundamentally important for deducing the influence of mechanical stimuli on traffic control through the necks, for example, in nuclear mechanosensing. In this work, we use computer simulations and theoretical analysis to investigate how neck size responds

SUBMITTER: Geiger BJ 

PROVIDER: S-EPMC12810485 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature