Effects of hypothermic oxygenated machine perfusion on bile composition after liver transplantation - Findings from a randomized controlled trial.

ABSTRACT:

Background & aims

In liver transplantation, bile acid (BA) toxicity contributes to injury of both hepatocytes and cholangiocytes. While hypothermic oxygenated machine perfusion (HOPE) reduces ischemia-reperfusion injury (IRI) and improves clinical outcomes, its impact on bile composition remains unclear because of the lack of bile samples available after LT.

Methods

Bile, blood, and liver tissue were collected within a multicentric randomized controlled trial (NCT03124641), from 26 patients receiving extended criteria donation (ECD) allografts from donors after brain death (DBD). Fourteen donor livers were static cold stored (SCS group), while 12 livers underwent end-ischemic HOPE. Grafts were randomly assigned. BA levels and metabolic parameters were analyzed across samples

SUBMITTER: Schliephake F 

PROVIDER: S-EPMC12810548 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature