The mature stem of green Asparagus as a potential dietary supplement for hyperuricemia: Asparagus ameliorates hyperuricemia by regulating hepatic uric acid metabolism and renal uric acid excretion.

ABSTRACT: Hyperuricemia (HUA) is a prevalent metabolic disorder and a major risk factor for gout and related complications, necessitating safe and effective management strategies. To this end, this study aimed to identify the most active part of asparagus, as a potent anti-HUA dietary supplement candidate and validate its efficacy and mechanism of action. LC-MS analysis identified that the Mature Stem of Green Asparagus (MSGA) possessed the richest flavonoid profile among asparagus fractions, with rutin content was 1.37 times higher than in other parts, and even 6.35 times higher. In a Drosophila melanogaster model of adenine-induced HUA, MSGA most effectively improved survival rates and climbing ability. Network pharmacology and molecular docking predicted 5'-nucleotidase ecto (Nt5e) and PDZ

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12810561 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature