From metabolomics to molecular docking: Unveiling the antioxidant potential of Ecuadorian <i>Hyeronima macrocarpa</i>.

ABSTRACT: Hyeronima macrocarpa ("motilón") is an underexplored tropical fruit. This study evaluated the antioxidant properties of its pulp and peel extracts obtained with 80 % acetone, MeOH-acetic acid (19:1), and H₂O-acetic acid (19,1). Total phenolic, flavonoid, anthocyanin, carotenoid, and tocopherol contents were determined, alongside radical scavenging activity (DPPH•), chelating capacity, electrochemical index (EI), and metabolomic profiling by UHPLC-MS. The MeOH-AcH (19,1). 80 % acetone extracts, especially from the peel, exhibited the highest total phenolic content, lowest EC₅₀ and TEC₅₀ values, and the strongest electrochemical responses, indicating superior redox activity. Metabolomic analysis identified abundant flavonols and anthocyanins with catechol or carbonyl groups, which lik

SUBMITTER: Gonzalez E 

PROVIDER: S-EPMC12810562 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature