Multifunctional injectable chitosan-based adhesive enhanced by limited oxidation for assisting bone grafting.

ABSTRACT: In clinical, critical bone defects are often treated with molded bone implants, yet they are prone to loosening, shape mismatch with the defect, and infection and inflammation. Herein, we present a limited oxidation strategy of catechol-chitosan (CC) to fabricate an injectable, adhesive, multifunctional nanocomposite hydrogel (OCCL) to assist bone implants in bone defects. Specifically, the oxidative cross-linking of CC within layered nanoclay (LAP) is moderately restricted to avoid excessive oxidation, thereby enhancing its adhesion to the tissue interface. By moderate oxidation of CC and the physical crosslinking boosted by LAP, the OCCL hydrogels show high adhesive strength, underwater adhesion, high antioxidant activity, good biodegradability and excellent antibacterial activity. Takin

SUBMITTER: Li S 

PROVIDER: S-EPMC12810563 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature