A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA Signaling.

ABSTRACT:

Background & aims

Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied. We previously identified the response to dsRNA as the most upregulated pathway across 2 distinct murine models of spasmolytic polypeptide-expressing metaplasia (SPEM), a critical pre-neoplastic transition in the progression to gastric cancer. The aim of this study was to define how dysregulation of the dsRNA response within gastric epithelium impacts gastric pre-neoplasia.

Methods

We specifically deleted ADAR1, a central regulator of dsRNA signaling, from gastric parietal cells (Adar1^ΔPC). Adar1^ΔPC and age-matched controls stomachs were histologically, transcrip

SUBMITTER: Halstead AM 

PROVIDER: S-EPMC12810565 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature