Integrated genomic, transcriptomic, and metabolomic profile analysis reveals molecular mechanism underlying meat quality traits in Chinese Kangle chickens.

ABSTRACT: The local Chinese Kangle chicken breed has plump muscles, tender-tasting meat, and strong disease resistance. We aimed to identify muscle metabolites and associated regulatory genes that determine Kangle chicken muscle quality and flavor by elucidating the as yet unknown underlying molecular regulatory mechanism through omics-based analyses. Phenotype analysis and genome-wide association study (GWAS) showed that intramuscular fat (IMF) exhibited a high coefficient of variation and identified two SNPs that reached genome-wide significance levels (P < 1.23 × 10^-6), with QTLs affecting IMF located on chromosomes 1, 2, 4, and 7. Transcriptome analysis screened 201 differential expression genes between chickens with high and low IMF content. Among these, the expression level o

SUBMITTER: He Q 

PROVIDER: S-EPMC12810574 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature