Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.

ABSTRACT: Metabolites in a urine extract are signal-enhanced by SABRE hyperpolarization and detected using a benchtop NMR spectrometer. Quantification by standard addition is demonstrated for endogenic urinary nicotinamide (vitamin B3). Even higher sensitivity is achieved in an automated setup for multi-scan SABRE experiments. This hyperpolarization scheme is able to expedite biomarker detection and quantification, while maintaining low infrastructure requirements.

SUBMITTER: Fleischer S 

PROVIDER: S-EPMC12810685 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature