Genetic and clinical determinants of neonatal jaundice and growth patterns in the Qingdao birth cohort: A genome-wide association study.

ABSTRACT:

Background

Neonatal jaundice and early growth patterns are important indicators of early health, and genetic as well as clinical factors are known to influence these traits. However, evidence from East Asian newborns is still limited.

Results

This study presents a genome-wide association study (GWAS) investigating genetic determinants of Healthy Newborn Growth Indicators (HNGI), with a focus on neonatal jaundice (JAU), jaundice resolution (JAUR), birth weight (BW), and growth metrics (weight, height, BMI) measured within 90-105 days after birth. Our analysis identified 778 single-nucleotide polymorphisms (SNPs) across 120 genes significantly associated with HNGI. Among these associated variants, we found 12 missense mutations, seven of which are novel. The most significant a

SUBMITTER: Chen X 

PROVIDER: S-EPMC12810793 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature