Drug-loaded nanoparticles for intra-articular injection.

ABSTRACT: Drug loaded nanoparticles (NPs) were developed as a model intra-articular injection (IAI) formulation to mitigate early stage osteoarthritis (OA). Different types of celecoxib-loaded nanoparticles were prepared by a hybrid method that combines homogenization and solvent evaporation. The hydrodynamic diameter of the nanoparticles prepared were approximately 200 nm (PLLA: 238 ± 19 nm; PCL: 249 ± 28 nm; PLA: 252 ± 18 nm; PMMA: 234 ± 21), and zeta potential were about -40 mV (PLLA: -45.3 ± 2.3 mV; PCL: -38.0 ± 0.9 mV; PLA: -44.4 ± 3.2 mV; PMMA: -45.5 ± 2.7 mV). Our friction data evidences that nanoparticles could improve considerably the lubrication between a stainless steel sphere and a silicone elastomer that were used as model substrates. Quartz Crystal Microbalance (QCM) and Atomic Force M

SUBMITTER: Pan P 

PROVIDER: S-EPMC12810800 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature