Skeletal muscle-kidney crosstalk in a cohort of critical illness survivors.

ABSTRACT:

Background

The skeletal muscles and kidneys are frequently affected during critical illness; however, their crosstalk remains poorly explored, especially in the long-term evolution. Therefore, we investigated the crosstalk between skeletal muscle and kidney function in COVID-19 survivors.

Methods

A cross-sectional analysis of a prospective cohort study with survivors of moderate to severe COVID-19 hospitalization. Skeletal muscle assessments included handgrip strength, calf circumference, ultrasound-measured quadriceps thickness, and gait speed test. Sarcopenia was diagnosed by modified EWGSOP2 (low handgrip strength plus low ultrasound-measured quadriceps thickness). Kidney function was assessed by estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine r

SUBMITTER: Ribeiro HS 

PROVIDER: S-EPMC12810808 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature