HELZ2 Regulates ApoB mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis.

ABSTRACT:

Background

Apolipoprotein B (apoB) is essential for lipoprotein assembly and secretion and plays a central role in the development of cardiovascular disease and metabolic dysfunction-associated steatotic liver disease. Although apoB protein degradation during very-low-density lipoprotein maturation has been extensively studied, the regulation of APOB mRNA stability under physiological and pathological conditions remains unexplored.

Methods

A forward genetic screen in randomly mutagenized mice identified HELZ2 (helicase with zinc finger 2) as a critical regulator of lipid metabolism. The metabolic effects of HELZ2 mutations or deficiency were evaluated in mice maintained on a chow diet or a high-fat diet. We also used a doxycycline-inducible, liver-specific HELZ2 overe

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12810863 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature