Zika virus infection in early pregnancy increases the likelihood of persistent neutralizing antibodies.

ABSTRACT:

Background

Neutralizing antibodies (nAbs) play a central role in protection against Zika virus (ZIKV) infection. Higher maternal ZIKV nAb titers during pregnancy have been associated with reduced risk of congenital anomalies. However, limited data exist on the long-term persistence of these antibodies in women infected during pregnancy and in children exposed in utero.

Methodology/principal findings

We conducted a cross-sectional serological study using stored serum samples from a cohort of mother-child pairs with confirmed maternal ZIKV infection during pregnancy in Campo Grande, Brazil. ZIKV nAb titers were measured in samples collected approximately 3-4 years after maternal infection using plaque reduction neutralization testing. Among 77 women, 66.2% (51/77) had ZIKV nAb

SUBMITTER: Falcao de Oliveira E 

PROVIDER: S-EPMC12810899 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature