Gamma irradiation crosslinked fluorescent nanocarbon based biodegradable hydrogel for controlled release of antibiotics.

ABSTRACT: Controlled and sustained antibiotic delivery is critical for combating antimicrobial resistance while minimizing side effects. Herein, a novel biodegradable hydrogel system, synthesized via gamma irradiation, incorporating fluorescent carbon dots (CDs) as multifunctional nano-crosslinkers, has been reported. The CDs, prepared from sustainable bio-precursors, reinforced the polymer network and enhanced the mechanical stability and swelling behavior, while simultaneously serving as intrinsic fluorescent probes for potential real-time monitoring of degradation and drug release. Thorough characterization revealed consistent morphology, adjustable biodegradability, and enhanced rheological characteristics. Drug release investigations demonstrated a diffusion-controlled mechanism, wherein the in

SUBMITTER: Vodeti R 

PROVIDER: S-EPMC12810907 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature