Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages.

ABSTRACT: Carbapenem-resistant K. pneumoniae (CRKP) are increasingly prevalent pathogens in hospital settings worldwide. In early 2019, an outbreak of carbapenem-resistant Enterobacterales (CRE) at a tertiary hospital in South Africa triggered a retrospective investigation to determine local CRKP molecular epidemiology. The evolution of CRE at the institution progressed from sporadic cases in 2016-2017 to establishment of CRKP as an endemic pathogen by 2020. Of 778 clinical and carriage CRKP isolates (2016-2020), 413 (53%) were collected and sequenced. Sequence type (ST) 2621 (164, 40%) and ST39 (164, 40%) predominated with several minor STs making up the remainder. The majority of ST2621 associated with blaOXA-181 were isolated from adult patients (59%) and clinical samples (84%). ST39 with blaNDM-

SUBMITTER: Moloto K 

PROVIDER: S-EPMC12810914 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature