Effect of Transcranial Direct Current Stimulation on Motor Speech in Nonfluent Primary Progressive Aphasia: A Case Report.

ABSTRACT:

Introduction

Primary progressive aphasia (PPA) is a neurodegenerative disorder that causes a gradual decline in language function. While combining transcranial direct current stimulation (tDCS) with rehabilitation of speech and language disorders (SLD rehab) has shown promise, its effect on motor speech disorders such as dysarthria and apraxia of speech (AOS), common in nonfluent variant PPA (nfvPPA), has been unclear.

Case presentation

This study used an N-of-1 crossover design to investigate the effects of SLD rehab-tDCS on articulation and vocalization in a 77-year-old male patient with nfvPPA, dysarthria, and AOS. In the intervention phase, intervention A (anodal tDCS over the left inferior frontal gyrus from the precentral regions, combined with SLD rehab) was compared

SUBMITTER: Ohashi Y 

PROVIDER: S-EPMC12810973 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature