Neuromyelitis Optica Spectrum Disorder Developing after COVID-19 Vaccination Managed with Long-Term Eculizumab Treatment: A Case Report.

ABSTRACT:

Introduction

Vaccine-associated neuromyelitis optica spectrum disorder (NMOSD) is rare, especially after COVID-19 vaccination. Furthermore, prior cases generally had specific symptoms.

Case presentation

We describe a patient who developed NMOSD following vaccination against COVID-19, whose initial symptoms were intractable hiccups and nausea. Thorough clinical examinations, including blood tests and imaging, immediately after symptom onset did not reveal any abnormal findings, and the anti-aquaporin-4 (AQP4) antibody titer was low. The patient's neurological symptoms (left side-dominant abnormal tingling sensation, touch allodynia, and muscle weakness) progressed. Approximately 5 months after symptom onset, a spinal cord lesion was found along the entire cervical cord that p

SUBMITTER: Uchida S 

PROVIDER: S-EPMC12810976 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature