Impact of statins on progression of coronary artery calcium composition and density as assessed by noncontrast CT.

ABSTRACT: The effect of statins on progression of coronary artery calcium (CAC) density as measured by noncontrast computed tomography (CT) remains unknown. We examined the association of statin therapy with temporal changes in compositional calcium density using quantitative assessment of CAC scoring CT. This was a retrospective, single-center study of asymptomatic individuals undergoing serial CAC scoring CT. Scans were analyzed using a fully automated deep learning model, with quantification of total CAC volume and volumes of calcium compositional subtypes stratified by Hounsfield unit (HU) density: 130-199; 200-299; 300-399; ≥400 HU. Of 316 patients (58.4 ± 10.1 years; 49.1% male) with CAC present at baseline and rescanned at a mean interval of 3.8 ± 1.7 years, 175 (55.4%) patients were statin-t

SUBMITTER: Giovannucci J 

PROVIDER: S-EPMC12810987 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature