Neuroimaging and Transcriptomic Insights Into Iron Accumulation and Glymphatic Dysfunction in Olfactory Dysfunction.

ABSTRACT:

Background

Olfactory dysfunction (OD) is clinically linked to inflammation and neurotoxin accumulation, yet the underlying neurobiological mechanisms remain largely unclear. Understanding how glymphatic function, iron dysregulation, and transcriptomic signatures contribute to OD may reveal new biomarkers and mechanisms of recovery.

Methods

A multimodal MRI framework integrating BOLD-CSF coupling, quantitative susceptibility mapping (QSM), and transcriptomic profiling was applied to post-viral (PVOD), post-traumatic (PTOD), and healthy control (HC) groups. Iron accumulation was quantified with QSM and linked to gene expression using partial least squares regression, followed by GO and protein-protein interaction analyses.

Results

PVOD showed significantly increased iro

SUBMITTER: Leong C 

PROVIDER: S-EPMC12811075 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature