Correlation between histologic chorioamnionitis and severe retinopathy of prematurity.

ABSTRACT:

Background

Retinopathy of prematurity (ROP) is influenced by factors, including gestational age (GA), oxygen exposure, and chorioamnionitis. However, the association between histologic chorioamnionitis (HCA) and ROP remains controversial. This study aimed to investigate the association between HCA and severe ROP.

Methods

This retrospective cohort study utilized data from the National Korean Neonatal Network registry, focusing on infants with birthweights < 1500 g and GA < 32 weeks. Univariate and multivariate logistic regression analyses assessed the association between HCA and severe ROP. Sub-cohort analyses were performed to evaluate the effect of HCA on severe ROP across different GA groups.

Results

Infants in the HCA cohort had lower GA and birth weights, with a h

SUBMITTER: Yoon YM 

PROVIDER: S-EPMC12811112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature