Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes.

ABSTRACT:

Background

The objective of this study was to examine the associations of blood inflammatory phenotypes with acute pediatric asthma exacerbations during different seasons and the COVID-19 pandemic.

Methods

A retrospective study was conducted involving 32,160 pediatric asthma patients from January 2008 to December 2021. Asthma blood inflammatory phenotypes were categorized based on low (L) and high (H) eosinophils (E) and neutrophils (N) (LBE/HBE: ≥ 0.25 × 10⁹/L and LBN/HBN: ≥ 5 × 10⁹/L, respectively) and logistic regression was used to examine the odds ratio (OR) of outcome variables.

Results

A 10⁹/L increase of neutrophils and eosinophils was associated with a 1.015-fold (95% CI: 1.009-1.021) and a 1.057-fold increase in the OR (95% C

SUBMITTER: Makrufardi F 

PROVIDER: S-EPMC12811121 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature