Severity of punctate white matter lesions in preterm infants: antecedents and cerebral palsy prediction.

ABSTRACT:

Background

The objectives were to investigate antecedent factors of punctate white matter lesions (PWML) severity on MRI at term-corrected age (CA) and to evaluate its ability to independently predict cerebral palsy (CP) in preterm infants.

Methods

We studied infants born at ≤32 weeks' gestational age [GA] with brain MRI at term CA, a standardized neuromotor exam to determine CP diagnosis, and composite scores from Bayley Scales of Infant and Toddler Development-III(BSID-III) at 2 years CA. MRIs with PWML were manually segmented and volume quantified with high reliability. We correlated >50 perinatal antecedent factors with PWML severity and conducted multivariable regression analyses to assess PWML ability to independently predict neurodevelopmental outcomes at age 2.

Re

SUBMITTER: Mahabee-Gittens EM 

PROVIDER: S-EPMC12811139 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature